This is a list of human pseudogenes that are known to be disabled genes.

  • WNT3A pseudogene, associated with the growth of a tail[1]
  • NCF1C pseudogene, associated with a type of white blood cell. It makes part of the neutrophil NADPH oxidase enzyme, which makes superoxide anion.[2][3]
  • GULO pseudogene, associated with the production of Vitamin C
  • IRGM pseudogene, associated with the immune system[4]
  • hHaA pseudogene, associated with fur-like body hair:[5] see hypertrichosis
  • DEFT1P pseudogene, associated with the immune system[6]
  • HTR5BP pseudogene, associated with a variant of the 5-HT5 receptor.[7]
  • Urate oxidase pseudogene, associated with the processing of uric acid
  • Photolyase pseudogene, associated with repairing DNA damaged by UV radiation.
    • Photolyase is no longer encoded for despite obvious advantages.[8] Instead, this gene is mutated to encode for cryptochromes.

References

  1. ↑ http://www.thephora.net/forum/archive/index.php/t-9928.html
  2. ↑ "NCF1C neutrophil cytosolic factor 1C pseudogene [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-10-14.
  3. ↑ "NCF1C Gene - GeneCards | NCF1C Pseudogene". www.genecards.org. Retrieved 2021-10-14.
  4. ↑ Plos genetics on IRGM pseudogene
  5. ↑ hHaA pseudogene
  6. ↑ Retrocyclin pseudogene reactivation as defense against AIDS
  7. ↑ "HTR5BP Gene - GeneCards | 5HTR5BP Pseudogene".
  8. ↑ Lucas-Lledó, José Ignacio; Lynch, Michael (2009-05-01). "Evolution of Mutation Rates: Phylogenomic Analysis of the Photolyase/Cryptochrome Family". Molecular Biology and Evolution. 26 (5): 1143–1153. doi:10.1093/molbev/msp029. ISSN 0737-4038. PMC 2668831. PMID 19228922.
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